National Biologics Facility
Our Publications
Peer-reviewed research and innovation supported by the National Biologics Facility.
NBF-Supported Research
Publication Archive
The National Biologics Facility has enabled more than 350 research publications.
202623
Acetate-Linked Energy Metabolism as a Determinant of Early Haemophilus influenzae Infection Fitness.
Bacterial reporter-paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense.
Bioinformatic pipeline to identify potential therapeutic targets with subsequent isolation and characterization of novel human anti-DDR1 antibodies
Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto).
Delineating the transcriptional and phenotypic impact from biotherapeutic glycoengineering
Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy
Enzyme-Assisted Synthesis and In Vitro Characterization of Bifunctional PCSK9 Inhibitors.
Indocyanine Green-Labeled Antibodies Cotargeting CDCP1 and Mesothelin for Fluorescence-Guided Imaging of Pancreatic Cancer
Lipid Nanoparticles with Side-Chain Polymer Coating for Targeted mRNA Delivery through Nanobody Attachment
Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response
Multiple defects in macrophage antibacterial responses support intracellular survival of Mycobacterium abscessus in cystic fibrosis
Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet-induced obesity.
Rapid expression of therapeutic antibodies in mammalian cells via mRNA transfection.
Rapid, Scalable, and Cost-Effective Manufacturing of Uniform Non-Enveloped, Tag-Free Virus-Like Particles.
Safety and immunogenicity of a SARS-CoV-2 spike, subunit vaccine stabilised in the prefusion conformation by second generation Molecular Clamp …
Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18-55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial.
Selective and Efficient Functionalization of P22 Virus-Like Particles Using an Asparaginyl Ligase
Preprint
Single Particle Tracking Photo-Activated Localization Microscopy
Structural basis of canonical TIR-NLR activation in plant innate immunity
Preprint
Systemically delivered mRNA-LNPs transfect primary and secondary liver tumors.
The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking
The Role of Glycan Structures in Modulating GM-CSF Bioactivity: Insights from Glycoengineering
Transmembrane orientation and extracellular juxtamembrane residues of GP130 are critical for signal transduction
202522
A nanobody-based therapeutic targeting Nipah virus limits viral escape
A novel chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses.
A protective bispecific antibody targets both Nipah virus surface glycoproteins and limits viral escape
Preprint
Assessing the therapeutic potential of a panel of novel VCAM-1 antibodies using microfluidic and three-dimensional in vitro models of vascular inflammation.
Australia's bioconjugate manufacturing: from research excellence to clinical translation
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11.
Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
Preprint
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function.
Detection of immune-mediated tumour cell death in vivo using Zirconium-89-labeled APOMAB®.
Di k, DM
Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CAR
Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity
Glycoengineering of the hepatitis C virus E2 glycoprotein leads to improved biochemical properties and enhanced immunogenicity
Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages.
New glucose-abstaining Chlorella algae doubles mammalian cell culture longevity, boosts performance and drops serum needs enabling scaled applications
Preprint
Nipah virus vaccines evaluated in pigs as a 'One Health' approach to protect public health.
Production of recombinant coiled coil silk proteins for materials synthesis.
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells.
Systematic evaluation of vector sequence elements in isogenic CHO cells for improved antibody production
The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice.
The search for crown-of-thorns starfish (COTS) pheromone attractants: modifying adult conspecific behaviour to control outbreaks
Yeast as a tool for exploring disulfide-rich peptides.
202434
A scalable, spin-free approach to generate enhanced induced pluripotent stem cell-derived natural killer cells for cancer immunotherapy
Amino acid degradation pathway inhibitory by-products trigger apoptosis in CHO cells.
Analytical Sensitivity Analysis and Clinical Impact Modeling of Rapigen Rapid Diagnostic Tests for Malaria.
Baculovirus-Assisted Production of Bartonella bacilliformis Proteins: A Potential Strategy for Improving Serological Diagnosis of Carrion's Disease.
Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo
Preprint
CFTR is required for zinc-mediated antibacterial defense in human macrophages.
Click‐on Antibody Fragments for Customisable Targeted Nanomedicines–Site‐specific Tetrazine and Azide Functionalisation through Non‐canonical Amino Acid …
Development and preliminary validation of a MERS-CoV ELISA for serological testing of camels and alpacas
Development of Lyophilized Eukaryotic Cell-Free Protein Expression System Based on Leishmania tarentolae.
Effective parallel evaluation of molecular design, expression and bioactivity of novel recombinant butyrylcholinesterase medical countermeasures.
EGFR Targeting of Liposomal Doxorubicin Improves Recognition and Suppression of Non-Small Cell Lung Cancer.
Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling
Genome-wide transcriptome profiling reveals molecular
Glycoengineered Recombinant Alpha1‐Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma‐Derived Protein
Handbook of Molecular Biotechnology
Book
Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
iLipidome: enhancing statistical power and interpretability using hidden biosynthetic interdependencies in the lipidome
Preprint
Isolation and Characterization of Antibodies Against Vascular Cell Adhesion Molecule-1 Reveals Putative Role for Ig-like Domains 2 and 3 in Cell-to-Cell Interaction.
Isolation and Characterization of Antibodies Against VCAM-1 Reveals Putative Role for Ig-like Domains 2 and 3 in Cell-to-Cell Interaction
Preprint
LeGenD: determining N-glycoprofiles using an explainable AI-leveraged model with lectin profiling
Limited potential of sheep as a large animal to model transfusion-related acute lung injury mediated by antibodies against human neutrophil antigen 3a
Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis.
Messenger RNA-encoded antibody approach for targeting extracellular and intracellular tau.
mRNArchitect: Optimized design of mRNA sequences
Poly-γ-glutamylation of biomolecules.
Protein structure, a genetic encoding for glycosylation
Preprint
Rational Design of Advanced Gene Delivery Carriers: Macrophage Phenotype Matters
Saturated fatty acid-Coenzyme A supplementation restores neuronal energy levels, synaptic function, and protein homeostasis in hereditary spastic paraplegia
Preprint
SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling
Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma.
Targeted mRNA delivery with bispecific antibodies that tether LNPs to cell-surface markers
The DmsABC S-oxide reductase is an essential component of a novel, hypochlorite-inducible system of extracellular stress defense in Haemophilus influenzae.
The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy
The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis
202321
A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants.
Assembly of immunogenic protein particles toward advanced synthetic vaccines
Biosurfactant stabilized nanoemulsions as multifunctional magnetically targeted delivery vehicles
Preprint
Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine.
Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme.
Caspase-4 dimerisation and D289 auto-processing elicits an interleukin-1β converting enzyme
Preprint
Characterisation of two snake toxin-targeting human monoclonal immunoglobulin G antibodies expressed in tobacco plants
Comparing different techniques for obtaining molecular size distributions of glycogen
Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia
Interim results from a phase I randomized, placebo-controlled trial of novel SARS-CoV-2 beta variant receptor-binding domain recombinant protein and mRNA vaccines as a 4th dose booster.
Interim Results from a Phase I Trial of Novel SARS-CoV-2 Beta Variant Receptor-Binding Domain Recombinant Protein and mRNA Vaccines as a 4 th Dose Booster
Preprint
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release
Mutations in the Vicinity of the IRAK3 Guanylate Cyclase Center Impact Its Subcellular Localization and Ability to Modulate Inflammatory Signaling in Immortalized Cell Lines.
Nutritional and techno-functional properties of Australian Acacia seed flour: Effects of roasting on chemical composition, physicochemical properties, and in vitro …
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.
Phage display assisted discovery of a pH‐dependent anti‐α‐cobratoxin antibody from a natural variable domain library
Preparing glycomics data for robust statistical analysis with GlyCompareCT
Recent advances in the production of recombinant factor IX: bioprocessing and cell engineering
Structure–Function relationship of Australian Acacia seed protein concentrates: Amino acid composition, in vitro protein digestibility and molecular properties
Targeted Hyperbranched Nanoparticles for Delivery of Doxorubicin in Breast Cancer Brain Metastasis.
TLR4 phosphorylation at tyrosine 672 activates the ERK/c-FOS signaling module for LPS-induced cytokine responses in macrophages.
202240
A platform technology for generating subunit vaccines against diverse viral pathogens.
Ambient Temperature Stable, Scalable COVID-19 Polymer Particle Vaccines Induce Protective Immunity.
An alpaca-derived nanobody recognizes a unique conserved epitope and retains potent activity against the SARS-CoV-2 omicron variant
Preprint
An alternative downstream translation start site in the non-TIR adaptor Scimp enables selective amplification of CpG DNA responses in mouse macrophages.
Approche intégrée de la lutte contre la tique du bétail, Rhipicephalus (Boophilus) australis, en Nouvelle-Calédonie
Bioproduction of Cyclic Disulfide-Rich Peptides for Drug Modalities
Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine
Preprint
Cold atmospheric plasma for preventing infection of viruses that use ACE2 for entry.
CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy.
Current status and future challenges in transitioning to continuous bioprocessing of virus‐like particles
Design and optimization of membrane chromatography for monoclonal antibody charge variant separation.
Detection of Dengue virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes
Engineering death resistance in CHO cells for improved perfusion culture.
Evaluation of Phage Display Biopanning Strategies for the Selection of Anti-Cell Surface Receptor Antibodies.
Evidence for overwintering and autochthonous transmission of Usutu virus to wild birds following its redetection in the United Kingdom.
Evidence of maternal transfer of antigen-specific antibodies in serum and breast milk to infants at high-risk of S. pneumoniae and H. influenzae disease.
Expanding the HPSE2 Genotypic Spectrum in Urofacial Syndrome, A Disease Featuring a Peripheral Neuropathy of the Urinary Bladder.
Field efficacy assessment of a vaccine against Rhipicephalus (Boophilus) australis in New-Caledonia
Highly Selective Lysine Acylation in Proteins Using a Lys‐His Tag Sequence
Improving stability enhances in vivo efficacy of a PCSK9 inhibitory peptide
Influence of DNA-protein interactions on purification and assembly of virus-like particles
Conference
Longitudinal field survey during deployment of an emergency autogenous vaccine against Betanodavirus in farmed giant grouper (Epinephelus lanceolatus) …
Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication
Preprint
Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization
Ornithine lipid activates both TLR4 and the non-canonical NLRP3 inflammasome
Preprint
Ornithine Lipid is a Partial TLR4 Agonist and NLRP3 Activator
Preprint
Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications.
Potential Application of Recombinant Snake Prothrombin Activator Ecarin in Blood Diagnostics.
Protein Expression Optimization Strategies in E. coli: A Tailored Approach in Strain Selection and Parallelizing Expression Conditions.
Quantifying regulated mitochondrial fission in macrophages
SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation.
Snake Venom Hydrogels as a Rapid Hemostatic Agent for Uncontrolled Bleeding.
Strategies for developing a recombinant butyrylcholinesterase medical countermeasure for Organophosphorus poisoning.
Surface SV2A-Syt1 nanoclusters act as a sequestration hub that limits dynamin-1 recruitment and targeting to recycling synaptic vesicles
Preprint
The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms
The Impact of Chromate on Pseudomonas aeruginosa Molybdenum Homeostasis.
The vaccinia-based Sementis Copenhagen Vector coronavirus disease 2019 vaccine induces broad and durable cellular and humoral immune responses.
Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy
Unexpected off-target activities for recombinant C5a in human macrophages
What are housekeeping genes?
202137
Aggregates in blood filter chambers used from the plasma donations of anti-D donors: evaluation for monoclonal antibody discovery using phage display.
Alessandro T. Caputo1, 3Ε, Oliver M. Eder1, 3, Hana Bereznakova1, Heleen Pothuis1
Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay
Bioactive cyclization optimizes the affinity of a proprotein convertase subtilisin/kexin type 9 (PCSK9) peptide inhibitor
Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product.
Combinatorial F-G Immunogens as Nipah and Respiratory Syncytial Virus Vaccine Candidates.
Comparative evaluation of integrated purification pathways for bacterial modular polyomavirus major capsid protein VP1 to produce virus-like particles using high throughput process technologies.
Complete protection by a single dose skin patch delivered SARS-CoV-2 spike vaccine
Preprint
Complete protection by a single-dose skin patch-delivered SARS-CoV-2 spike vaccine.
Diagnostic Characteristics of Lactate Dehydrogenase on a Multiplex Assay for Malaria Detection Including the Zoonotic Parasite Plasmodium knowlesi.
Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9)
Enzyme mediated incorporation of zirconium-89 or copper-64 into a fragment antibody for same day imaging of epidermal growth factor receptor.
Frontline Science: LPS-inducible SLC30A1 drives human macrophage-mediated zinc toxicity against intracellular Escherichia coli.
Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection
Impact of photobiomodulation using four diode laser wavelengths of on cationic liposome gene transfection into pre-osteoblast cells
In vitro, classical complement activation differs by disease severity and between SARS-CoV-2 antigens
Preprint
Incorporation of Unnatural Amino Acid into Antibody Fragment for Creating a Stable Antibody-Drug Conjugate.
Intensified Downstream Processing of Monoclonal Antibodies Using Membrane Technology.
Modified horseshoe crab peptides target and kill bacteria inside host cells.
Morphology and composition of immunodiffusion precipitin complexes evaluated via microscopy and proteomics
Mutational and biophysical robustness in a prestabilized monobody
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption.
Positron Emission Tomographic Imaging of Tumor Cell Death Using Zirconium-89-Labeled APOMAB® Following Cisplatin Chemotherapy in Lung and Ovarian Cancer Xenograft Models.
Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2.
Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery
Recombinant antibody engineering enables reversible binding for continuous protein biosensing
Smart Vaccine Design Keeps Manufacturability in Mind: Upstream and downstream advances include simpler bioconjugation, increasingly stable structures, filters for …
Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection
Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins.
Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy
Targeting Cross-Presentation as a Route to Improve the Efficiency of Peptide-Based Cancer Vaccines.
Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication.
Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice.
The vaccinia-based Sementis Copenhagen Vector COVID-19 vaccine induces broad and durable cellular and humoral immune responses
Preprint
Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release.
Virus‐like particle preparation is improved by control over capsomere‐DNA interactions during chromatographic purification
Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases.
202028
'Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells
A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells.
An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides
Analysis of coagulation factor IX in bioreactor cell culture medium predicts yield and quality of the purified product
Preprint
Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production
Bisphosphonate Stabilized Calcium Phosphate Nanoparticles for Effective Delivery of Plasmid DNA to Macrophages
Bovine Herpesvirus-4-Vectored Delivery of Nipah Virus Glycoproteins Enhances T Cell Immunogenicity in Pigs.
Characterization of the Biodistribution of a Silica Vesicle Nanovaccine Carrying a Rhipicephalus (Boophilus) microplus Protective Antigen With in vivo Live Animal Imaging.
Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses.
Effect of solid-state fermentation on proximate composition, anti-nutritional factor, microbiological and functional properties of lupin flour
Engineering an optimized analgesic from the NaV1. 7 selective spider venom peptide Pn3a
Genetic mapping using a wheat multi-founder population reveals a locus on chromosome 2A controlling resistance to both leaf and glume blotch caused by the necrotrophic fungal pathogen Parastagonospora nodorum.
Improved non-invasive positron emission tomographic imaging of chemotherapy-induced tumor cell death using Zirconium-89-labeled APOMAB®.
Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
Mapping the molecular surface of the analgesic NaV1. 7-selective peptide Pn3a reveals residues essential for membrane and channel interactions
Molecular clamp stabilised Spike protein for protection against SARS-CoV-2
Preprint
MR-guided focused ultrasound increases antibody delivery to nonenhancing high-grade glioma.
Neuro-Oncology Advances
Physicochemical, Microbiological and Functional Properties of Camelina Meal Fermented in Solid-State Using Food Grade Aspergillus Fungi
Progress Curve Analysis of the one stage chromogenic assay for ecarin
Protein Expression in the Baculovirus-Insect Cell Expression System.
Rapid Application of the Molecular Clamp Platform for SARS-CoV-2
Preprint
Recombinant production, bioconjugation and membrane binding studies of Pn3a, a selective NaV1. 7 inhibitor
Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first-in …
Solid-state fermentation of canola meal with Aspergillus sojae, Aspergillus ficuum and their co-cultures: Effects on physicochemical, microbiological and functional …
Synthetic biology in Australia
The interaction between Glycophorin A (GPA) and Band 3 in the formation of the Wright b (Wrb) antigen
Tumour-associated macrophages process drug and radio-conjugates of the dead tumour cell-targeting APOMAB® antibody.
201924
A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus
Antibody-Binding, Antifouling Surface Coatings Based on Recombinant Expression of Zwitterionic EK Peptides.
APOMAB Antibody-Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo.
Bacillus anthracis Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell Carcinoma.
Cancer In-Vitro Diagnostics Using Upconversion Nanoprobe
Book
Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning.
Chimeric Murine Polyomavirus Virus-Like Particles Induce Plasmodium Antigen-Specific CD8+ T Cell and Antibody Responses.
Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545
Impact of site-specific bioconjugation on the interfacial activity of a protein biosurfactant
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Media composition modulates human embryonic stem cell morphology and may influence preferential lineage differentiation potential.
Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma.
Overall Nutritional and Sensory Profile of Different Species of Australian Wattle Seeds (Acacia spp.): Potential Food Sources in the Arid Semi-Arid Regions.
PD-L1- and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease.
Process simulation based decisional tool to evaluate strategies for continuous downstream bioprocess implementation-A CDMO perspective
Conference
Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes.
Retooling phage display with electrohydrodynamic nanomixing and nanopore sequencing
Synthetic biology for bioengineering virus-like particle vaccines.
Systems-level engineering and characterisation of Clostridium autoethanogenum through heterologous production of poly-3-hydroxybutyrate (PHB)
The Impact of Bioconjugation on the Interfacial Activity of a Protein Biosurfactant
Preprint
The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses
Use of bacteriophage for discovery of therapeutically relevant antibodies against infectious diseases
Vaccine Technology VII: Beyond the "decade of vaccines".
Wavelength-Dependent Fluorescent Immunosensors via Incorporation of Polarity Indicators near the Binding Interface of Antibody Fragments
201822
A novel antibody targeting tau phosphorylated at serine 235 detects neurofibrillary tangles
A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery.
Baculovirus-driven protein expression in insect cells: A benchmarking study.
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.
CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation.
CD83 antibody inhibits human B cell responses to antigen as well as dendritic cell–mediated CD4 T cell responses
Cost-effective downstream processing of recombinantly produced pexiganan peptide and its antimicrobial activity.
Electrostatic Interactions between Hendra Virus Matrix Proteins Are Required for Efficient Virus-Like-Particle Assembly.
Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach
H2 drives metabolic rearrangements in gas-fermenting Clostridium autoethanogenum.
Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and-independent secretion
MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression.
Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps
Novel sources of resistance to Septoria nodorum blotch in the Vavilov wheat collection identified by genome-wide association studies.
PLP1 Mutations in Patients with Multiple Sclerosis: Identification of a New Mutation and Potential Pathogenicity of the Mutations.
Progression of continuous downstream processing of monoclonal antibodies: Current trends and challenges.
Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria.
RNA-Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells.
Selection of antibodies to transiently expressed membrane proteins using phage display
Structural-based designed modular capsomere comprising HA1 for low-cost poultry influenza vaccination.
SYNTHETIC
Vaccine Technology VI: Innovative and integrated approaches in vaccine development.
201722
A partially purified outer membrane protein VirB9-1 for low-cost nanovaccines against Anaplasma marginale
Biosecurity.
Computational Identification of Antibody Epitopes on the Dengue Virus NS1 Protein.
Evaluation of expression systems of recombinant human interferon gamma
Evaluation of three adjuvants with respect to both adverse effects and the efficacy of antibody production to the Bm86 protein.
From folding to function: design of a new switchable biosurfactant protein
Immunization of a wild koala population with a recombinant Chlamydia pecorum Major Outer Membrane Protein (MOMP) or Polymorphic Membrane Protein (PMP) based vaccine: New insights into immune response, protection and clearance.
Integrated molecular and bioprocess engineering for bacterially produced immunogenic modular virus-like particle vaccine displaying 18 kDa rotavirus antigen.
Is Pichia pastoris a realistic platform for industrial production of recombinant human interferon gamma?
Isolation of serotype-specific antibodies against dengue virus non-structural protein 1 using phage display and application in a multiplexed serotyping assay.
LUA LHL 1
Maintenance of ATP Homeostasis Triggers Metabolic Shifts in Gas-Fermenting Acetogens.
Non‐chromatographic bioprocess engineering of a recombinant mineralizing protein for the synthesis of silica nanocapsules
Overexpression of the regulatory subunit of glutamate‐cysteine ligase enhances monoclonal antibody production in CHO cells
Platform technologies for modern vaccine manufacturing.
Preface.
Small-Molecule Inhibitors of the SOX18 Transcription Factor.
Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals.
Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis.
Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors
Targeting mesothelin receptors with drug-loaded bacterial nanocells suppresses human mesothelioma tumour growth in mouse xenograft models.
Using peptide aptamer targeted polymers as a model nanomedicine for investigating drug distribution in cancer nanotheranostics
201612
Avoidance of stochastic RNA interactions can be harnessed to control protein expression levels in bacteria and archaea.
Characterizing Enterovirus 71 and Coxsackievirus A16 virus-like particles production in insect cells.
Coronin 1B reorganizes the architecture of F-actin networks for contractility at steady-state and apoptotic adherens junctions
Design strategies to address the effect of hydrophobic epitope on stability and in vitro assembly of modular virus-like particle.
Immunogenicity of Outer Membrane Proteins VirB9-1 and VirB9-2, a Novel Nanovaccine against Anaplasma marginale.
Influenza nucleoprotein DNA vaccination by a skin targeted, dry coated, densely packed microprojection array (Nanopatch) induces potent antibody and …
LATERAL BRANCHING OXIDOREDUCTASE acts in the final stages of strigolactone biosynthesis in Arabidopsis.
Modular virus-like particles for sublingual vaccination against group A streptococcus.
Overcoming instability of antibody‐nanomaterial conjugates: Next generation targeted nanomedicines using bispecific antibodies
Preclinical immunogenicity and safety of a Group A streptococcal M protein-based vaccine candidate.
Targeting membrane proteins for antibody discovery using phage display.
Targeting Nanomedicines to Prostate Cancer: Evaluation of Specificity of Ligands to Two Different Receptors In Vivo Pearce, Fuchs, Fletcher and Thurecht
201520
Assembly and purification of polyomavirus-like particles from plants
Biomolecular engineering of virus-like particles aided by computational chemistry methods
Development of a surface plasmon resonance assay to measure the binding affinity of wild‐type influenza neuraminidase and its H274Y mutant to the antiviral drug …
EphA2 as a diagnostic imaging target in glioblastoma: a positron emission tomography/magnetic resonance imaging study
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions
Insert engineering and solubility screening improves recovery of virus-like particle subunits displaying hydrophobic epitopes.
Interfacial biomimetic synthesis of silica nanocapsules using a recombinant catalytic modular protein
Introduction.
Nanocell targeting using engineered bispecific antibodies.
Natural avoidance of stochastic mRNA: ncRNA interactions can be harnessed to control protein expression levels
Preprint
Non-carrier nanoparticles adjuvant modular protein vaccine in a particle-dependent manner.
Non-chromatographic preparation of a bacterially produced single-shot modular virus-like particle capsomere vaccine for avian influenza.
Predicting recombinant protein expression experiments using molecular dynamics simulation
Refining the Model of Plant Disease Resistance Protein Activation
Solution structure of the RNA-binding cold-shock domain of the Chlamydomonas reinhardtii NAB1 protein and insights into RNA recognition
SseK3 Is a Salmonella Effector That Binds TRIM32 and Modulates the Host's NF-κB Signalling Activity.
Synthetic biology design to display an 18 kDa rotavirus large antigen on a modular virus-like particle.
Systems analysis of methylerythritol-phosphate pathway flux in E. coli: insights into the role of oxidative stress and the validity of lycopene as an isoprenoid reporter metabolite.
Tailorable nanocarrier emulsion for drug delivery
The C-terminal end of the capsid protein of Avian Nephritis Virus is antigenic and induces broadly cross-reactive antibodies
201413
1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase
Bioengineering virus-like particles as vaccines.
Characterisation of a secretory serine protease inhibitor (SjB6) from Schistosoma japonicum.
Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation.
Energetic changes caused by antigenic module insertion in a virus-like particle revealed by experiment and molecular dynamics simulations.
Functional characterization of SjB10, an intracellular serpin from Schistosoma japonicum
Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccines
Intensified expression and purification of a recombinant biosurfactant protein
Microbially synthesized modular virus‐like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants
Production of the short peptide surfactant DAMP4 from glucose or sucrose in high cell density cultures of Escherichia coli BL21(DE3).
Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: extending the potential of broadly cross-protecting epitopes.
Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation
The efficacy of Raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer-specific nanoclustering.
20139
A novel pathogenesis-related protein (LcPR4a) from lentil, and its involvement in defence against Ascochyta lentis
Effects of pre‐existing anti‐carrier immunity and antigenic element multiplicity on efficacy of a modular virus‐like particle vaccine
Modular engineering of a microbially-produced viral capsomere vaccine for influenza
Molecular energetics in the capsomere of virus-like particle revealed by molecular dynamics simulations
Polymerase chain reaction-based screening for the ceftriaxone-resistant Neisseria gonorrhoeae F89 strain
Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particle
Subunit organisation of in vitro reconstituted HOPS and CORVET multisubunit membrane tethering complexes.
The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane
The production and engineering of antimicrobial peptides and their application in the coating of urinary catheters
20127
A multi-omics analysis of recombinant protein production in Hek293 cells.
Bacterial expression of a VLP Sub-unit for rapid and cheap influenza vaccination
Conference
Biopharmaceutical production technology, 2 volume set
Book
BPN 2012: Talking heads
Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide.
Resources, reputation and ROl: Why industry and government look to universities for research outcomes
The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum
20115
A chromatography-focused bioprocess that eliminates soluble aggregation for bioactive production of a new antimicrobial peptide candidate
Bridging the gap: facilities and technologies for development of early stage therapeutic mAb candidates.
Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation.
Synthesis of simple heparanase substrates
Virus identification and development of long-term management strategies for the rhubarb industry
20103
20094
Adsorptive refolding of a highly disulfide-bonded inclusion body protein using anion-exchange chromatography
Microbial bio‐production of a recombinant stimuli‐responsive biosurfactant
Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction.
Robotics: Proteins R'us
20086
Binding mode of α-conotoxins to an acetylcholine binding protein determined by saturation transfer difference NMR
Bioengineering mass-manufacturable viral vaccines for pandemic influenza
Effect of cycle ratio on biodegradation of azo dye in sequencing batch reactor
Encapsulation of DNA and non-viral protein changes the structure of murine polyomavirus virus-like particles
Identification of immune genes and proteins involved in the response of bovine mammary tissue to Staphylococcus aureus infection.
Single-site Cys-substituting mutation of human lectin galectin-2: modulating solubility in recombinant production, reducing long-term aggregation, and enabling site …
20073
Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase: a protease involved in amino acid regulation with potential for antimalarial drug …
Crystallization and preliminary X-ray diffraction of the Munc18c-syntaxin4 (1-29) complex.
Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch.
20062
20051
Metabolic engineering of hyaluronic acid production
20001
Faculty of 1000 evaluation for Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch
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