Process Development and Scale Up

As programs move from development to the clinic, it is imperative to establish a data package around each of the upstream, downstream, and supporting analytical testing needs to reproducibly manufacture the protein of interest.

Single-Use Systems

Single-use product contact surfaces helps mitigate the risk of cross contamination and to drive efficiencies within NBF operations. A range of process scales is available with single-use options from bench to 50 L bioreactor.

Upstream Process Development

Upstream development focuses on optimising the process with a clinical or Good Manufacturing Practice (GMP) manufacturing in mind, utilising small-scale technologies through to a single-use 50 L bioreactor.

Purification Development

The NBF customizes protein purification and downstream development using industry-relevant technologies to ensure the end product is stable, fit for purpose and meets your target purity profile requirements.. We support everything from research-enabling protein preparations to gram-scale outputs suitable for Phase I clinical use.

Bioanalytics & Characterisation

The NBF has state-of-the-art laboratory analysis equipment, coupled with proven analytical method development expertise to build the data package assessing protein quantity, purity, quality, and stability.

Analytical Testing Capabilities

Formulation Screening

The NBF has advanced formulation screening equipment to accelerate the formulation development process. Coupled with proven analytical expertise this ensures that your protein remains stable and effective.

The NBF accelerates formulation development with advanced screening technologies, ensuring protein therapeutics remain stable, potent, and fit for purpose. Our integrated approach supports efficient identification of optimal formulations tailored to your product’s specific requirements.