OUR CAPABILITIES
Transient and Stable Expression
We have extensive experience producing a wide range of recombinant proteins in different mammalian host cells, and will work with you to determine the optimal expression host, transfection method, purification strategy and analytical characterisation for your protein needs.
Mammalian Expression Systems
We offer the choice of mammalian host cell lines for biologics production. Transient expression offers rapid production of recombinant protein for early-stage research, while stable expression provides higher yields and development towards large-scale manufacture.
High Throughput Clone Selection
The NBF utilises automated systems such as the Beacon Optofluidics Platform to accelerate the identification and outgrowth of single cell derived mammalian clones. The platform considers manufacturability endpoints through coupling with high throughput assays to screen for high producers and associated characterisation analysis to ensure lead clones meet required process and product quality attributes.
Mammalian Cell Line Development
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Host cell lines chosen for production of research cell banks within the NBF are manufactured under cGMP and released with robust characterisation and biosafety testing. The NBF operates under a Quality Management System (QMS) with intent to control and manage materials, facility, and production processes in order to mitigate contamination risks for introduction of adventitious agents into the manufactured products.
Phase Appropriate
Manufacture For Early Phase Studies
We have extensive experience (>15 years) of assisting clients in translating their science and novel therapeutic targets to support clinical end points. The NBF recognises that an appropriate quality system that governs activities which may bridge early stage biotherapeutics development and cGMP production is a valuable attribute which underpins the development of high-quality biopharmaceuticals.
